{"number":"US12696884B2","kindCode":"B2","documentType":"grant","title":{"original":"Genetically modified non-human animals expressing human EPO","english":"Genetically modified non-human animals expressing human EPO"},"abstract":{"original":"Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g.…","english":"Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g.…"},"applicants":["Institute for Research in Biomedicine (IRB)","Yale University","Regeneron Pharmaceuticals, Inc."],"inventors":["Andrew J. Murphy","Sean Stevens","Richard Flavell","Markus Gabriel Manz","Liang Shan"],"filingDate":"2023-08-10","publicationDate":"2026-08-04","grantDate":"2026-08-04","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12696884B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12696884B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12696884B2","ja":"https://downloadpatent.com/ja/patent/US12696884B2"}}