{"number":"US12697328B2","kindCode":"B2","documentType":"grant","title":{"original":"Methods for treating metastasis with cathepsin C inhibitors","english":"Methods for treating metastasis with cathepsin C inhibitors"},"abstract":{"original":"Provided herein are methods for treating metastasis of a cancer with a pharmaceutical composition comprising an effective amount of a cathepsin C (CTSC) inhibitor. The CTSC inhibitor, in some embodiments, is a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for example, brensocatib. The treatment methods inhibit, slow, or reverse the progression of the metastasis. In some embodiments, the methods further comprise reducing neutrophil infiltration and/or formation of neutrophil extracellular traps (NETs).","english":"Provided herein are methods for treating metastasis of a cancer with a pharmaceutical composition comprising an effective amount of a cathepsin C (CTSC) inhibitor. The CTSC inhibitor, in some embodiments, is a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for example, brensocatib. The treatment methods inhibit, slow, or reverse the progression of the metastasis. In some embodiments, the methods further comprise reducing neutrophil infiltration and/or formation of neutrophil extracellular traps (NETs)."},"applicants":["Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences"],"inventors":["Guohong HU","Yansen XIAO","Min CONG","Chenxi LIANG"],"filingDate":"2023-03-08","publicationDate":"2026-08-04","grantDate":"2026-08-04","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12697328B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12697328B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12697328B2","ja":"https://downloadpatent.com/ja/patent/US12697328B2"}}