{"number":"US12697379B2","kindCode":"B2","documentType":"grant","title":{"original":"Pegylated tetanus neurotoxins and treatment of hypotonia","english":"Pegylated tetanus neurotoxins and treatment of hypotonia"},"abstract":{"original":"The invention relates to a composition comprising a first PEGylated tetanus neurotoxin (PEG-TeNT) comprising tetanus neurotoxin (TeNT) conjugated to polyethylene glycol (PEG) and a second TeNT. The invention also relates to various PEG-TeNTs. The invention also relates to a method of treating hypotonia using the composition or various PEG-TeNTs, and a kit comprising the composition or various PEG-TeNTs. In one embodiment, the hypotonia is obstructive sleep apnoea.","english":"The invention relates to a composition comprising a first PEGylated tetanus neurotoxin (PEG-TeNT) comprising tetanus neurotoxin (TeNT) conjugated to polyethylene glycol (PEG) and a second TeNT. The invention also relates to various PEG-TeNTs. The invention also relates to a method of treating hypotonia using the composition or various PEG-TeNTs, and a kit comprising the composition or various PEG-TeNTs. In one embodiment, the hypotonia is obstructive sleep apnoea."},"applicants":["Snoretox Pty Ltd"],"inventors":["Thomas McLean","Peter Smooker","Luke Norbury","Peter Coloe","Russell Conduit","Anthony Sasse"],"filingDate":"2021-01-21","publicationDate":"2026-08-04","grantDate":"2026-08-04","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12697379B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12697379B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12697379B2","ja":"https://downloadpatent.com/ja/patent/US12697379B2"}}