{"number":"US12697391B2","kindCode":"B2","documentType":"grant","title":{"original":"Bi-functional molecules to degrade circulating proteins","english":"Bi-functional molecules to degrade circulating proteins"},"abstract":{"original":"Described herein is a bi-functional compound for removing macrophage migration inhibitory factor (MIF) or immunoglobin G (IgG). Further described herein is a pharmaceutical composition which comprise these bi-functional compounds. Further described herein is a method for treating disease states and/or conditions with the compounds or the composition. The disease states and/or conditions are mediated through MIF/IgG or where MIF/IgG is a contributing factor to the development and perpetuation of diseases and/or conditions, such as autoimmune diseases and cancer, among others.","english":"Described herein is a bi-functional compound for removing macrophage migration inhibitory factor (MIF) or immunoglobin G (IgG). Further described herein is a pharmaceutical composition which comprise these bi-functional compounds. Further described herein is a method for treating disease states and/or conditions with the compounds or the composition. The disease states and/or conditions are mediated through MIF/IgG or where MIF/IgG is a contributing factor to the development and perpetuation of diseases and/or conditions, such as autoimmune diseases and cancer, among others."},"applicants":["YALE UNIVERSITY"],"inventors":["David Spiegel","David Caianiello"],"filingDate":"2022-03-15","publicationDate":"2026-08-04","grantDate":"2026-08-04","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12697391B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12697391B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12697391B2","ja":"https://downloadpatent.com/ja/patent/US12697391B2"}}