{"number":"US12697397B2","kindCode":"B2","documentType":"grant","title":{"original":"Modified adeno-associated virus vectors and delivery thereof into the central nervous system","english":"Modified adeno-associated virus vectors and delivery thereof into the central nervous system"},"abstract":{"original":"The present invention relates to modified adeno-associated virus (AAV) vectors for use in transducing a cell in the central nervous system (CNS) of a subject, and for use in the prevention or treatment of a CNS disease. In particular, the modified AAV vectors according to the present invention comprise at least one surface-bound saccharide, and are to be administered directly to the CNS but not intracerebroventricularly.","english":"The present invention relates to modified adeno-associated virus (AAV) vectors for use in transducing a cell in the central nervous system (CNS) of a subject, and for use in the prevention or treatment of a CNS disease. In particular, the modified AAV vectors according to the present invention comprise at least one surface-bound saccharide, and are to be administered directly to the CNS but not intracerebroventricularly."},"applicants":["Coave Therapeutics"],"inventors":["Philippe Moullier","Willem Broekaert"],"filingDate":"2022-06-24","publicationDate":"2026-08-04","grantDate":"2026-08-04","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12697397B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12697397B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12697397B2","ja":"https://downloadpatent.com/ja/patent/US12697397B2"}}