{"number":"US12697403B2","kindCode":"B2","documentType":"grant","title":{"original":"Small molecules for dual function positron emission tomography (PET) and cell suicide switches","english":"Small molecules for dual function positron emission tomography (PET) and cell suicide switches"},"abstract":{"original":"The present invention includes an engineered cell comprising a chimeric antigen receptor (CAR) further comprising a nucleic acid molecule comprising a suicide gene comprising a ligand binding domain and a suicide domain wherein the ligand binding domain is capable of binding to radiolabeled tracer or a small molecule suicide switch.…","english":"The present invention includes an engineered cell comprising a chimeric antigen receptor (CAR) further comprising a nucleic acid molecule comprising a suicide gene comprising a ligand binding domain and a suicide domain wherein the ligand binding domain is capable of binding to radiolabeled tracer or a small molecule suicide switch.…"},"applicants":["THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA"],"inventors":["Michael Farwell","Mark Sellmyer","Katheryn M. Lohith"],"filingDate":"2022-01-14","publicationDate":"2026-08-04","grantDate":"2026-08-04","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12697403B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12697403B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12697403B2","ja":"https://downloadpatent.com/ja/patent/US12697403B2"}}