{"number":"US12697491B2","kindCode":"B2","documentType":"grant","title":{"original":"System and method for affecting porosity of tissue barriers, including blood brain barrier, and delivery of active agents","english":"System and method for affecting porosity of tissue barriers, including blood brain barrier, and delivery of active agents"},"abstract":{"original":"Systems, devices, and methods for modulating permeability of a membrane barrier (e.g., BBB), such as by increasing and/or decreasing porosity of the membrane barrier. The membrane barrier may be modulated indirectly through neuromodulation, which may include stimulation of an upstream neural body (e.g., a ganglion) that affects, either directly or indirectly, the permeability of the membrane barrier. Modulating a membrane barrier has uses in selective delivery of active agents or other substances through the membrane barrier into tissues or cells.…","english":"Systems, devices, and methods for modulating permeability of a membrane barrier (e.g., BBB), such as by increasing and/or decreasing porosity of the membrane barrier. The membrane barrier may be modulated indirectly through neuromodulation, which may include stimulation of an upstream neural body (e.g., a ganglion) that affects, either directly or indirectly, the permeability of the membrane barrier. Modulating a membrane barrier has uses in selective delivery of active agents or other substances through the membrane barrier into tissues or cells.…"},"applicants":["Realeve, LLC"],"inventors":["Peter M. Bonutti","Justin E. Beyers"],"filingDate":"2025-08-19","publicationDate":"2026-08-04","grantDate":"2026-08-04","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12697491B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12697491B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12697491B2","ja":"https://downloadpatent.com/ja/patent/US12697491B2"}}