{"number":"US12702122B2","kindCode":"B2","documentType":"grant","title":{"original":"Non-human animals comprising a humanized ACE2 locus","english":"Non-human animals comprising a humanized ACE2 locus"},"abstract":{"original":"Non-human animal cells and non-human animals comprising a humanized ACE2 locus and methods of using such non-human animal cells and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized ACE2 locus express a human ACE2 protein or a chimeric ACE2 protein, fragments of which are from human ACE2. Methods are also provided for using such non-human animals comprising a humanized ACE2 locus to assess in vivo ACE2 activity, e.g., coronavirus infection and/or the treatment or prevention thereof.","english":"Non-human animal cells and non-human animals comprising a humanized ACE2 locus and methods of using such non-human animal cells and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized ACE2 locus express a human ACE2 protein or a chimeric ACE2 protein, fragments of which are from human ACE2. Methods are also provided for using such non-human animals comprising a humanized ACE2 locus to assess in vivo ACE2 activity, e.g., coronavirus infection and/or the treatment or prevention thereof."},"applicants":["Regeneron Pharmaceuticals, Inc."],"inventors":["Susannah Brydges","Christos Kyratsous","Alina Baum"],"filingDate":"2022-12-16","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702122B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702122B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702122B2","ja":"https://downloadpatent.com/ja/patent/US12702122B2"}}