{"number":"US12702478B2","kindCode":"B2","documentType":"grant","title":{"original":"Devices, methods, and compositions for thermal acceleration and drug delivery","english":"Devices, methods, and compositions for thermal acceleration and drug delivery"},"abstract":{"original":"A thermal accelerant can be used as a drug delivery vehicle to deliver one or more drugs to a target site. For example, in some embodiments, a carrier such as albumin or human serum albumin (HSA) can be impregnated with, or covalently attached to, an anti-tumor agent and delivered to a location proximate to a tumor of a patient. The carrier can be exposed to an energy source that structurally alters the carrier and releases the agent therefrom. The sources of energy can include one or more of microwave, radiofrequency, electrical pulse (electroporation) or sonar (HIFU or histotripsy).…","english":"A thermal accelerant can be used as a drug delivery vehicle to deliver one or more drugs to a target site. For example, in some embodiments, a carrier such as albumin or human serum albumin (HSA) can be impregnated with, or covalently attached to, an anti-tumor agent and delivered to a location proximate to a tumor of a patient. The carrier can be exposed to an energy source that structurally alters the carrier and releases the agent therefrom. The sources of energy can include one or more of microwave, radiofrequency, electrical pulse (electroporation) or sonar (HIFU or histotripsy).…"},"applicants":["Brown University","Rhode Island Hospital"],"inventors":["William Keun Chan Park","Damian E. Dupuy"],"filingDate":"2022-05-23","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702478B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702478B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702478B2","ja":"https://downloadpatent.com/ja/patent/US12702478B2"}}