{"number":"US12702648B2","kindCode":"B2","documentType":"grant","title":{"original":"Telodendrimer nanocarriers for monomeric amphotericin B delivery","english":"Telodendrimer nanocarriers for monomeric amphotericin B delivery"},"abstract":{"original":"Systemic fungal infections are an increasingly prevalent health problem. Amphotericin B (AmB), a hydrophobic polyene antibiotic, remains the drug of choice for life-threatening invasive fungal infections. Embodiments disclosed herein are directed telodendrimer (TD) nanocarriers having freely engineered core structures for AmB encapsulation to reduce AmB aggregation status. The reduced aggregation status correlates with the optimized antifungal activity and the attenuated hemolytic properties, as well as reduced cytotoxicity to mammalian cells.…","english":"Systemic fungal infections are an increasingly prevalent health problem. Amphotericin B (AmB), a hydrophobic polyene antibiotic, remains the drug of choice for life-threatening invasive fungal infections. Embodiments disclosed herein are directed telodendrimer (TD) nanocarriers having freely engineered core structures for AmB encapsulation to reduce AmB aggregation status. The reduced aggregation status correlates with the optimized antifungal activity and the attenuated hemolytic properties, as well as reduced cytotoxicity to mammalian cells.…"},"applicants":["The Research Foundation for the State University of New York"],"inventors":["Juntao Luo","Xiaotian Ji","Changying Shi"],"filingDate":"2024-01-30","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702648B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702648B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702648B2","ja":"https://downloadpatent.com/ja/patent/US12702648B2"}}