{"number":"US12702658B2","kindCode":"B2","documentType":"grant","title":{"original":"Anticancer combination therapy with N-(1-acryloyl-azetidin-3-yl)-2-((1H-indazol-3-yl)amino)methyl)-1H-imidazole-5-carboxamide inhibitor of KRAS-G12C","english":"Anticancer combination therapy with N-(1-acryloyl-azetidin-3-yl)-2-((1H-indazol-3-yl)amino)methyl)-1H-imidazole-5-carboxamide inhibitor of KRAS-G12C"},"abstract":{"original":"A method of treating cancer comprises administering: (a) a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof; and (b) a therapeutically effective amount of an additional anti-cancer agent, to a subject in need of such treatment, the compound of Formula (I) being: where X, R1, R2, ring A, L1, L2, L3, and R5 are as defined in this disclosure.","english":"A method of treating cancer comprises administering: (a) a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof; and (b) a therapeutically effective amount of an additional anti-cancer agent, to a subject in need of such treatment, the compound of Formula (I) being: where X, R1, R2, ring A, L1, L2, L3, and R5 are as defined in this disclosure."},"applicants":["Astex Therapeutics Ltd.","TAIHO PHARMACEUTICAL CO., LTD."],"inventors":["Tetsuya ABE","Yoko NAKATSURU","Hiroshi SOOTOME"],"filingDate":"2022-10-24","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702658B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702658B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702658B2","ja":"https://downloadpatent.com/ja/patent/US12702658B2"}}