{"number":"US12702665B2","kindCode":"B2","documentType":"grant","title":{"original":"ExoVII inhibitor and quinolone antibiotic combination useful for treating bacterial infection","english":"ExoVII inhibitor and quinolone antibiotic combination useful for treating bacterial infection"},"abstract":{"original":"The disclosure provides a method of treating or preventing a bacterial infection in a subject comprising administering a therapeutically effective amount of a combination of a bacterial type IIA topoisomerase inhibitor, or a pharmaceutically acceptable salt thereof and a compound Formula I, or a pharmaceutically acceptable salt thereof, to the subject, where the compound of Formula I is (Formula (I)) where the variables, e.g. Y1, Y2, and R1-R4, are described herein. The bacterial type IIA topoisomerase inhibitor can be a quinolone antibiotic such as ciprofloxacin.","english":"The disclosure provides a method of treating or preventing a bacterial infection in a subject comprising administering a therapeutically effective amount of a combination of a bacterial type IIA topoisomerase inhibitor, or a pharmaceutically acceptable salt thereof and a compound Formula I, or a pharmaceutically acceptable salt thereof, to the subject, where the compound of Formula I is (Formula (I)) where the variables, e.g. Y1, Y2, and R1-R4, are described herein. The bacterial type IIA topoisomerase inhibitor can be a quinolone antibiotic such as ciprofloxacin."},"applicants":["THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES"],"inventors":["Yves Georges Pommier","Shar-yin Naomi Huang"],"filingDate":"2023-06-20","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702665B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702665B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702665B2","ja":"https://downloadpatent.com/ja/patent/US12702665B2"}}