{"number":"US12702693B2","kindCode":"B2","documentType":"grant","title":{"original":"Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR","english":"Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR"},"abstract":{"original":"The present invention provides, among other things, methods of treating cystic fibrosis, comprising a step of administering to a subject in need of treatment a composition comprising an mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, wherein the mRNA encoding the CFTR protein comprises a polynucleotide sequence at least 80% identical to SEQ ID NO: 1, wherein the mRNA is at a concentration of at least 0.4 mg/mL, and wherein the step of administering comprises inhalation.","english":"The present invention provides, among other things, methods of treating cystic fibrosis, comprising a step of administering to a subject in need of treatment a composition comprising an mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, wherein the mRNA encoding the CFTR protein comprises a polynucleotide sequence at least 80% identical to SEQ ID NO: 1, wherein the mRNA is at a concentration of at least 0.4 mg/mL, and wherein the step of administering comprises inhalation."},"applicants":["Translate Bio, Inc."],"inventors":["Michael Heartlein","Frank DeRosa","Alan Kimura","Jonathan Abysalh","Anusha Dias","Shrirang Karve","Zarna Patel"],"filingDate":"2021-10-01","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702693B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702693B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702693B2","ja":"https://downloadpatent.com/ja/patent/US12702693B2"}}