{"number":"US12702696B2","kindCode":"B2","documentType":"grant","title":{"original":"Methods and composition for modulating immune response and immune homeostasis","english":"Methods and composition for modulating immune response and immune homeostasis"},"abstract":{"original":"The present invention discloses novel methods, uses thereof, and compositions for modulating immune responses and homeostasis in a lymph node (LN). Moreover, structural and molecular characteristics of LN-innervating sensory neurons are provided. The present invention also discloses the target cells for LN-innervating sensory neurons in LN and molecular profiles of these target cells. These molecular characteristics provide therapeutic targets for modulating immune response and immune homeostasis in LN in an animal or a human.","english":"The present invention discloses novel methods, uses thereof, and compositions for modulating immune responses and homeostasis in a lymph node (LN). Moreover, structural and molecular characteristics of LN-innervating sensory neurons are provided. The present invention also discloses the target cells for LN-innervating sensory neurons in LN and molecular profiles of these target cells. These molecular characteristics provide therapeutic targets for modulating immune response and immune homeostasis in LN in an animal or a human."},"applicants":["President and Fellows of Harvard College","Massachusetts Institute of Technology"],"inventors":["Carly G.K. Ziegler","Siyi Huang","Ulrich H. von Andrian","Alexander K. Shalek"],"filingDate":"2020-10-16","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702696B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702696B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702696B2","ja":"https://downloadpatent.com/ja/patent/US12702696B2"}}