{"number":"US12702706B2","kindCode":"B2","documentType":"grant","title":{"original":"Methods of preparing anti-human papillomavirus antigen T cells","english":"Methods of preparing anti-human papillomavirus antigen T cells"},"abstract":{"original":"Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy.…","english":"Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments; separately culturing the multiple fragments; obtaining T cells from the cultured multiple fragments; testing the T cells for specific autologous HPV-positive tumor recognition; selecting the T cells that exhibit specific autologous HPV-positive tumor recognition; and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy.…"},"applicants":["The United States of America,as represented by the Secretary,Department of Health and Human Services"],"inventors":["Christian S. Hinrichs","Steven A. Rosenberg"],"filingDate":"2024-02-01","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702706B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702706B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702706B2","ja":"https://downloadpatent.com/ja/patent/US12702706B2"}}