{"number":"US12702715B2","kindCode":"B2","documentType":"grant","title":{"original":"Targeted RNA degradation allows precision repurposing of protein-targeted small molecule medicines to RNA","english":"Targeted RNA degradation allows precision repurposing of protein-targeted small molecule medicines to RNA"},"abstract":{"original":"The protein targeted medicine, Dovitinib, has been repurposed to target a non-coding RNA by using selection and computational drug design via Inforna. Selectivity was achieved for pre-miR-21 by endowing the medicine with the ability to recruit RNA quality control enzymes to cleave the target.","english":"The protein targeted medicine, Dovitinib, has been repurposed to target a non-coding RNA by using selection and computational drug design via Inforna. Selectivity was achieved for pre-miR-21 by endowing the medicine with the ability to recruit RNA quality control enzymes to cleave the target."},"applicants":["University of Florida Research Foundation, Incorporated"],"inventors":["Matthew D. Disney"],"filingDate":"2023-01-30","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702715B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702715B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702715B2","ja":"https://downloadpatent.com/ja/patent/US12702715B2"}}