{"number":"US12702720B2","kindCode":"B2","documentType":"grant","title":{"original":"Genomic insulator element exhibiting enhancer blocking activities in lymphocytes and uses thereof","english":"Genomic insulator element exhibiting enhancer blocking activities in lymphocytes and uses thereof"},"abstract":{"original":"A construct including a genomic insulator element that exhibits strong enhancer blocking activities in T lymphocytes is provided as are host cells, pharmaceutical compositions and methods of using the construct in the treatment of disease, in particular a disease to be treated with a retroviral vector-modified T lymphocyte.","english":"A construct including a genomic insulator element that exhibits strong enhancer blocking activities in T lymphocytes is provided as are host cells, pharmaceutical compositions and methods of using the construct in the treatment of disease, in particular a disease to be treated with a retroviral vector-modified T lymphocyte."},"applicants":["ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC."],"inventors":["Sheng ZHOU","Brian SORRENTINO","Yong CHENG"],"filingDate":"2022-11-10","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702720B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702720B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702720B2","ja":"https://downloadpatent.com/ja/patent/US12702720B2"}}