{"number":"US12702722B2","kindCode":"B2","documentType":"grant","title":{"original":"Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations","english":"Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations"},"abstract":{"original":"Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in GABAergic neurons generally; and/or GABAergic neuron cell types such as lysosomal associated membrane protein 5 (Lamp5) neurons; vasoactive intestinal polypeptide-expressing (Vip) neurons; somatostatin (Sst) neurons; and/or parvalbumin (Pvalb) neuron cell types.…","english":"Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in GABAergic neurons generally; and/or GABAergic neuron cell types such as lysosomal associated membrane protein 5 (Lamp5) neurons; vasoactive intestinal polypeptide-expressing (Vip) neurons; somatostatin (Sst) neurons; and/or parvalbumin (Pvalb) neuron cell types.…"},"applicants":["Allen Institute"],"inventors":["Jonathan Ting","Boaz P. Levi","Bosiljka Tasic","John K. Mich","Erik Hess","Edward Sebastian Lein","Lucas T. Graybuck","Tanya Daigle","Hongkui Zeng"],"filingDate":"2021-08-13","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702722B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702722B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702722B2","ja":"https://downloadpatent.com/ja/patent/US12702722B2"}}