{"number":"US12702870B2","kindCode":"B2","documentType":"grant","title":{"original":"Mechanical pulsed ultrasound therapy for modulating neural tissue microenvironments","english":"Mechanical pulsed ultrasound therapy for modulating neural tissue microenvironments"},"abstract":{"original":"Short ultrasound pulses or bursts, delivered at intermediate intensity to the target brain tissue transmits acoustic radiation forces into the targeted brain tissue without generating acoustic cavitation and without cellular fractionization. Thus, the present invention exploits the mechanical effects of high-intensity pressure fields only, without cavitation, by optimizing the interaction between acoustic pulses and radiation forces to apply a negative pressure to the brain tissue and degrading the perineuronal nets in the brain tissue and opening the blood-brain barrier.","english":"Short ultrasound pulses or bursts, delivered at intermediate intensity to the target brain tissue transmits acoustic radiation forces into the targeted brain tissue without generating acoustic cavitation and without cellular fractionization. Thus, the present invention exploits the mechanical effects of high-intensity pressure fields only, without cavitation, by optimizing the interaction between acoustic pulses and radiation forces to apply a negative pressure to the brain tissue and degrading the perineuronal nets in the brain tissue and opening the blood-brain barrier."},"applicants":["Wisconsin Alumni Research Foundation"],"inventors":["John-Paul Yu"],"filingDate":"2023-05-23","publicationDate":"2026-08-11","grantDate":"2026-08-11","verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US12702870B2.pdf","pages":{"en":"https://downloadpatent.com/patent/US12702870B2","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US12702870B2","ja":"https://downloadpatent.com/ja/patent/US12702870B2"}}