{"number":"US20120329858A1","kindCode":"A1","documentType":"publication","title":{"original":"Modified oligonucleotides for telomerase inhibition","english":"Modified oligonucleotides for telomerase inhibition"},"abstract":{"original":"Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.","english":"Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics."},"applicants":["Geron Corp"],"inventors":["Sergei GRYAZNOV","Krisztina Pongracz"],"filingDate":"2012-08-21","publicationDate":"2012-12-27","grantDate":null,"verifiedWithOffice":true,"pdfUrl":"https://downloadpatent.com/pdf/US20120329858A1.pdf","pages":{"en":"https://downloadpatent.com/patent/US20120329858A1","zh-Hant":"https://downloadpatent.com/zh-Hant/patent/US20120329858A1","ja":"https://downloadpatent.com/ja/patent/US20120329858A1"}}