美國
US 12,697,328 B2
Methods for treating metastasis with cathepsin C inhibitors
US 12,697,328 B2 是美國專利商標局（USPTO）的核准專利，日期 2026-08-04。申請人：Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences。PDF 可在本頁下載，未登入每天最多 5 篇。
- 申請人
- Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
- 發明人
- Guohong HU; Yansen XIAO; Min CONG; Chenxi LIANG
- 公開日
- 2026-08-04
- 申請日
- 2023-03-08
- 文件種類
- B2 核准公告
- 也寫作
- US 12,697,328 B2 · US12697328 · 12697328
摘要
Provided herein are methods for treating metastasis of a cancer with a pharmaceutical composition comprising an effective amount of a cathepsin C (CTSC) inhibitor. The CTSC inhibitor, in some embodiments, is a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for example, brensocatib. The treatment methods inhibit, slow, or reverse the progression of the metastasis. In some embodiments, the methods further comprise reducing neutrophil infiltration and/or formation of neutrophil extracellular traps (NETs).
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專利局網站： 美國專利商標局（USPTO）