美國
US 12,702,122 B2
Non-human animals comprising a humanized ACE2 locus
US 12,702,122 B2 是美國專利商標局（USPTO）的核准專利，日期 2026-08-11。申請人：Regeneron Pharmaceuticals, Inc.。PDF 可在本頁下載，未登入每天最多 5 篇。
- 申請人
- Regeneron Pharmaceuticals, Inc.
- 發明人
- Susannah Brydges; Christos Kyratsous; Alina Baum
- 公開日
- 2026-08-11
- 申請日
- 2022-12-16
- 文件種類
- B2 核准公告
- 也寫作
- US 12,702,122 B2 · US12702122 · 12702122
摘要
Non-human animal cells and non-human animals comprising a humanized ACE2 locus and methods of using such non-human animal cells and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized ACE2 locus express a human ACE2 protein or a chimeric ACE2 protein, fragments of which are from human ACE2. Methods are also provided for using such non-human animals comprising a humanized ACE2 locus to assess in vivo ACE2 activity, e.g., coronavirus infection and/or the treatment or prevention thereof.
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專利局網站： 美國專利商標局（USPTO）