美國
US 12,702,648 B2
Telodendrimer nanocarriers for monomeric amphotericin B delivery
US 12,702,648 B2 是美國專利商標局（USPTO）的核准專利，日期 2026-08-11。申請人：The Research Foundation for the State University of New York。PDF 可在本頁下載，未登入每天最多 5 篇。
- 申請人
- The Research Foundation for the State University of New York
- 發明人
- Juntao Luo; Xiaotian Ji; Changying Shi
- 公開日
- 2026-08-11
- 申請日
- 2024-01-30
- 文件種類
- B2 核准公告
- 也寫作
- US 12,702,648 B2 · US12702648 · 12702648
摘要
Systemic fungal infections are an increasingly prevalent health problem. Amphotericin B (AmB), a hydrophobic polyene antibiotic, remains the drug of choice for life-threatening invasive fungal infections. Embodiments disclosed herein are directed telodendrimer (TD) nanocarriers having freely engineered core structures for AmB encapsulation to reduce AmB aggregation status. The reduced aggregation status correlates with the optimized antifungal activity and the attenuated hemolytic properties, as well as reduced cytotoxicity to mammalian cells.…
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專利局網站： 美國專利商標局（USPTO）