美國
US 12,702,693 B2
Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR
US 12,702,693 B2 是美國專利商標局（USPTO）的核准專利，日期 2026-08-11。申請人：Translate Bio, Inc.。PDF 可在本頁下載，未登入每天最多 5 篇。
- 申請人
- Translate Bio, Inc.
- 發明人
- Michael Heartlein; Frank DeRosa; Alan Kimura; Jonathan Abysalh; Anusha Dias; Shrirang Karve; Zarna Patel
- 公開日
- 2026-08-11
- 申請日
- 2021-10-01
- 文件種類
- B2 核准公告
- 也寫作
- US 12,702,693 B2 · US12702693 · 12702693
摘要
The present invention provides, among other things, methods of treating cystic fibrosis, comprising a step of administering to a subject in need of treatment a composition comprising an mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, wherein the mRNA encoding the CFTR protein comprises a polynucleotide sequence at least 80% identical to SEQ ID NO: 1, wherein the mRNA is at a concentration of at least 0.4 mg/mL, and wherein the step of administering comprises inhalation.
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專利局網站： 美國專利商標局（USPTO）