United States
US 12,696,884 B2
Genetically modified non-human animals expressing human EPO
US 12,696,884 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-04. Applicant: Institute for Research in Biomedicine (IRB); Yale University; Regeneron Pharmaceuticals, Inc. Its PDF downloads from this page without an account, up to 5 a day.
- Applicant
- Institute for Research in Biomedicine (IRB); Yale University; Regeneron Pharmaceuticals, Inc.
- Inventors
- Andrew J. Murphy; Sean Stevens; Richard Flavell; Markus Gabriel Manz; Liang Shan
- Publication date
- 2026-08-04
- Filing date
- 2023-08-10
- Document type
- B2 Granted patent
- Also written as
- US 12,696,884 B2 · US12696884 · 12696884
Abstract
Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g.…
The opening of the abstract. The full text is in the PDF.
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Patent office website: United States Patent and Trademark Office (USPTO)
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