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United States

US 12,696,897 B2

Cryopreserving macrophages

US 12,696,897 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-04. Applicant: The University Court of The University of Edinburgh. Its PDF downloads from this page without an account, up to 5 a day.

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Applicant
The University Court of The University of Edinburgh
Inventors
Stuart Forbes; Lara Campana; Benjamin Dwyer; John Campbell; Alasdair Fraser
Publication date
2026-08-04
Filing date
2022-11-25
Document type
B2 Granted patent
Also written as
US 12,696,897 B2 · US12696897 · 12696897

Abstract

The present invention relates to a method of improving the viability of macrophages subjected to cryopreservation, particularly for macrophages which are to be used in therapy, wherein the method comprises a step of maintaining the macrophages at a temperature of 2-12° C. for at least 30 minutes during either freezing or thawing procedures. Following the holding step during cooling, a cooling rate of 1 to 5° C. is used until the macrophages in a medium are frozen. For thawing the macrophages, a warming rate of 1 to 5° C. per minute is used until a temperature of 35-37° C. is reached.…

The opening of the abstract. The full text is in the PDF.

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