United States
US 12,697,328 B2
Methods for treating metastasis with cathepsin C inhibitors
US 12,697,328 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-04. Applicant: Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences. Its PDF downloads from this page without an account, up to 5 a day.
- Applicant
- Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
- Inventors
- Guohong HU; Yansen XIAO; Min CONG; Chenxi LIANG
- Publication date
- 2026-08-04
- Filing date
- 2023-03-08
- Document type
- B2 Granted patent
- Also written as
- US 12,697,328 B2 · US12697328 · 12697328
Abstract
Provided herein are methods for treating metastasis of a cancer with a pharmaceutical composition comprising an effective amount of a cathepsin C (CTSC) inhibitor. The CTSC inhibitor, in some embodiments, is a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for example, brensocatib. The treatment methods inhibit, slow, or reverse the progression of the metastasis. In some embodiments, the methods further comprise reducing neutrophil infiltration and/or formation of neutrophil extracellular traps (NETs).
The opening of the abstract. The full text is in the PDF.
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Patent office website: United States Patent and Trademark Office (USPTO)
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