United States
US 12,697,391 B2
Bi-functional molecules to degrade circulating proteins
US 12,697,391 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-04. Applicant: YALE UNIVERSITY. Its PDF downloads from this page without an account, up to 5 a day.
- Applicant
- YALE UNIVERSITY
- Inventors
- David Spiegel; David Caianiello
- Publication date
- 2026-08-04
- Filing date
- 2022-03-15
- Document type
- B2 Granted patent
- Also written as
- US 12,697,391 B2 · US12697391 · 12697391
Abstract
Described herein is a bi-functional compound for removing macrophage migration inhibitory factor (MIF) or immunoglobin G (IgG). Further described herein is a pharmaceutical composition which comprise these bi-functional compounds. Further described herein is a method for treating disease states and/or conditions with the compounds or the composition. The disease states and/or conditions are mediated through MIF/IgG or where MIF/IgG is a contributing factor to the development and perpetuation of diseases and/or conditions, such as autoimmune diseases and cancer, among others.
The opening of the abstract. The full text is in the PDF.
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Patent office website: United States Patent and Trademark Office (USPTO)
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