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United States

US 12,697,397 B2

Modified adeno-associated virus vectors and delivery thereof into the central nervous system

US 12,697,397 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-04. Applicant: Coave Therapeutics. Its PDF downloads from this page without an account, up to 5 a day.

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Applicant
Coave Therapeutics
Inventors
Philippe Moullier; Willem Broekaert
Publication date
2026-08-04
Filing date
2022-06-24
Document type
B2 Granted patent
Also written as
US 12,697,397 B2 · US12697397 · 12697397

Abstract

The present invention relates to modified adeno-associated virus (AAV) vectors for use in transducing a cell in the central nervous system (CNS) of a subject, and for use in the prevention or treatment of a CNS disease. In particular, the modified AAV vectors according to the present invention comprise at least one surface-bound saccharide, and are to be administered directly to the CNS but not intracerebroventricularly.

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Patent office website: United States Patent and Trademark Office (USPTO)

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