United States
US 12,697,491 B2
System and method for affecting porosity of tissue barriers, including blood brain barrier, and delivery of active agents
US 12,697,491 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-04. Applicant: Realeve, LLC. Its PDF downloads from this page without an account, up to 5 a day.
- Applicant
- Realeve, LLC
- Inventors
- Peter M. Bonutti; Justin E. Beyers
- Publication date
- 2026-08-04
- Filing date
- 2025-08-19
- Document type
- B2 Granted patent
- Also written as
- US 12,697,491 B2 · US12697491 · 12697491
Abstract
Systems, devices, and methods for modulating permeability of a membrane barrier (e.g., BBB), such as by increasing and/or decreasing porosity of the membrane barrier. The membrane barrier may be modulated indirectly through neuromodulation, which may include stimulation of an upstream neural body (e.g., a ganglion) that affects, either directly or indirectly, the permeability of the membrane barrier. Modulating a membrane barrier has uses in selective delivery of active agents or other substances through the membrane barrier into tissues or cells.…
The opening of the abstract. The full text is in the PDF.
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Patent office website: United States Patent and Trademark Office (USPTO)
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