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United States

US 12,702,478 B2

Devices, methods, and compositions for thermal acceleration and drug delivery

US 12,702,478 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-11. Applicant: Brown University; Rhode Island Hospital. Its PDF downloads from this page without an account, up to 5 a day.

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Applicant
Brown University; Rhode Island Hospital
Inventors
William Keun Chan Park; Damian E. Dupuy
Publication date
2026-08-11
Filing date
2022-05-23
Document type
B2 Granted patent
Also written as
US 12,702,478 B2 · US12702478 · 12702478

Abstract

A thermal accelerant can be used as a drug delivery vehicle to deliver one or more drugs to a target site. For example, in some embodiments, a carrier such as albumin or human serum albumin (HSA) can be impregnated with, or covalently attached to, an anti-tumor agent and delivered to a location proximate to a tumor of a patient. The carrier can be exposed to an energy source that structurally alters the carrier and releases the agent therefrom. The sources of energy can include one or more of microwave, radiofrequency, electrical pulse (electroporation) or sonar (HIFU or histotripsy).…

The opening of the abstract. The full text is in the PDF.

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Patent office website: United States Patent and Trademark Office (USPTO)

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