United States
US 12,702,665 B2
ExoVII inhibitor and quinolone antibiotic combination useful for treating bacterial infection
US 12,702,665 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-11. Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES. Its PDF downloads from this page without an account, up to 5 a day.
- Applicant
- THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Inventors
- Yves Georges Pommier; Shar-yin Naomi Huang
- Publication date
- 2026-08-11
- Filing date
- 2023-06-20
- Document type
- B2 Granted patent
- Also written as
- US 12,702,665 B2 · US12702665 · 12702665
Abstract
The disclosure provides a method of treating or preventing a bacterial infection in a subject comprising administering a therapeutically effective amount of a combination of a bacterial type IIA topoisomerase inhibitor, or a pharmaceutically acceptable salt thereof and a compound Formula I, or a pharmaceutically acceptable salt thereof, to the subject, where the compound of Formula I is (Formula (I)) where the variables, e.g. Y1, Y2, and R1-R4, are described herein. The bacterial type IIA topoisomerase inhibitor can be a quinolone antibiotic such as ciprofloxacin.
The opening of the abstract. The full text is in the PDF.
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Patent office website: United States Patent and Trademark Office (USPTO)
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