United States
US 12,702,693 B2
Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR
US 12,702,693 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-11. Applicant: Translate Bio, Inc. Its PDF downloads from this page without an account, up to 5 a day.
- Applicant
- Translate Bio, Inc.
- Inventors
- Michael Heartlein; Frank DeRosa; Alan Kimura; Jonathan Abysalh; Anusha Dias; Shrirang Karve; Zarna Patel
- Publication date
- 2026-08-11
- Filing date
- 2021-10-01
- Document type
- B2 Granted patent
- Also written as
- US 12,702,693 B2 · US12702693 · 12702693
Abstract
The present invention provides, among other things, methods of treating cystic fibrosis, comprising a step of administering to a subject in need of treatment a composition comprising an mRNA encoding a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, wherein the mRNA encoding the CFTR protein comprises a polynucleotide sequence at least 80% identical to SEQ ID NO: 1, wherein the mRNA is at a concentration of at least 0.4 mg/mL, and wherein the step of administering comprises inhalation.
The opening of the abstract. The full text is in the PDF.
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Patent office website: United States Patent and Trademark Office (USPTO)
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