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United States

US 12,702,715 B2

Targeted RNA degradation allows precision repurposing of protein-targeted small molecule medicines to RNA

US 12,702,715 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-11. Applicant: University of Florida Research Foundation, Incorporated. Its PDF downloads from this page without an account, up to 5 a day.

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Applicant
University of Florida Research Foundation, Incorporated
Inventors
Matthew D. Disney
Publication date
2026-08-11
Filing date
2023-01-30
Document type
B2 Granted patent
Also written as
US 12,702,715 B2 · US12702715 · 12702715

Abstract

The protein targeted medicine, Dovitinib, has been repurposed to target a non-coding RNA by using selection and computational drug design via Inforna. Selectivity was achieved for pre-miR-21 by endowing the medicine with the ability to recruit RNA quality control enzymes to cleave the target.

The opening of the abstract. The full text is in the PDF.

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Patent office website: United States Patent and Trademark Office (USPTO)

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