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United States

US 12,702,722 B2

Artificial expression constructs for selectively modulating gene expression in selected neuronal cell populations

US 12,702,722 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-11. Applicant: Allen Institute. Its PDF downloads from this page without an account, up to 5 a day.

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Applicant
Allen Institute
Inventors
Jonathan Ting; Boaz P. Levi; Bosiljka Tasic; John K. Mich; Erik Hess; Edward Sebastian Lein; Lucas T. Graybuck; Tanya Daigle; Hongkui Zeng
Publication date
2026-08-11
Filing date
2021-08-13
Document type
B2 Granted patent
Also written as
US 12,702,722 B2 · US12702722 · 12702722

Abstract

Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in GABAergic neurons generally; and/or GABAergic neuron cell types such as lysosomal associated membrane protein 5 (Lamp5) neurons; vasoactive intestinal polypeptide-expressing (Vip) neurons; somatostatin (Sst) neurons; and/or parvalbumin (Pvalb) neuron cell types.…

The opening of the abstract. The full text is in the PDF.

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