United States
US 12,702,870 B2
Mechanical pulsed ultrasound therapy for modulating neural tissue microenvironments
US 12,702,870 B2 is a granted patent from the United States Patent and Trademark Office (USPTO), dated 2026-08-11. Applicant: Wisconsin Alumni Research Foundation. Its PDF downloads from this page without an account, up to 5 a day.
- Applicant
- Wisconsin Alumni Research Foundation
- Inventors
- John-Paul Yu
- Publication date
- 2026-08-11
- Filing date
- 2023-05-23
- Document type
- B2 Granted patent
- Also written as
- US 12,702,870 B2 · US12702870 · 12702870
Abstract
Short ultrasound pulses or bursts, delivered at intermediate intensity to the target brain tissue transmits acoustic radiation forces into the targeted brain tissue without generating acoustic cavitation and without cellular fractionization. Thus, the present invention exploits the mechanical effects of high-intensity pressure fields only, without cavitation, by optimizing the interaction between acoustic pulses and radiation forces to apply a negative pressure to the brain tissue and degrading the perineuronal nets in the brain tissue and opening the blood-brain barrier.
The opening of the abstract. The full text is in the PDF.
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Patent office website: United States Patent and Trademark Office (USPTO)
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