United States
US 20120329858 A1
Modified oligonucleotides for telomerase inhibition
US 20120329858 A1 is a published patent application from the United States Patent and Trademark Office (USPTO), dated 2012-12-27. Applicant: Geron Corp. Its PDF downloads from this page without an account, up to 5 a day.
- Applicant
- Geron Corp
- Inventors
- Sergei GRYAZNOV; Krisztina Pongracz
- Publication date
- 2012-12-27
- Filing date
- 2012-08-21
- Document type
- A1 Published application
- Also written as
- US 20120329858 A1 · US 2012/0329858 A1
Abstract
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
The opening of the abstract. The full text is in the PDF.
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Patent office website: United States Patent and Trademark Office (USPTO)
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